Details

Autor(en) / Beteiligte

• Cantoral, A
• Montoya, A
• Luna‐Villa, L
• Roldán‐Valadez, EA
• Hernández‐Ávila, M
• Kershenobich, D
• Perng, W
• Peterson, KE
• Hu, H
• Rivera, JA
• Téllez‐Rojo, MM

Titel

Overweight and obesity status from the prenatal period to adolescence and its association with non‐alcoholic fatty liver disease in young adults: cohort study

Ist Teil von

• BJOG : an international journal of obstetrics and gynaecology, 2020-09, Vol.127 (10), p.1200-1209

Ort / Verlag

England: Wiley Subscription Services, Inc

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• Objective To examine the associations of maternal and child overweight status across multiple time‐points with liver fat content in the offspring during young adulthood. Design Cohort study. Setting ELEMENT Cohort in Mexico City. Population Pregnant women with singleton births (n = 97). Methods We quantified hepatic triglyceride content (liver fat content) by proton magnetic resonance spectroscopy (1H MRS) and conventional T2‐weighted MRIs (3T scanner) in 97 young adults from the ELEMENT birth cohort in Mexico City. Historical records of the cohort were used as a source of pregnancy, and childhood and adolescence anthropometric information, overweight and obesity (OWOB) were defined. Adjusted structural equation models were run to identify the association between OWOB in different life stages with liver fat content (log‐transformed) in young adulthood. Main outcome Maternal OWOB at the time of delivery was directly and indirectly associated with the liver fat content in the offspring at young adulthood. Results Seventeen percent of the participants were classified as having NAFLD. We found a strong association of OWOB between all periods assessed. Maternal OWOB at time of delivery (β = 1.97, 95% CI 1.28–3.05), and OWOB status in the offspring at young adulthood (β = 3.17, 95% CI 2.10–4.77) were directly associated with the liver fat content in the offspring. Also, maternal OWOB was indirectly associated with liver fat content through offspring OWOB status. Conclusion We found that maternal OWOB status is related to fatty liver content in the offspring as young adults, even after taking into account OWOB status and lifestyle factors in the offspring. Tweetable There was an association between pre‐pregnancy overweight and the development of NAFLD in adult offspring. Tweetable There was an association between pre‐pregnancy overweight and the development of NAFLD in adult offspring.