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Over the past decade, data recorded (due to digitization) in healthcare sectors have continued to increase, intriguing the thought about big data in healthcare. There already exists plenty of information, ready for analysis. Researchers are always putting their best effort to find valuable insight from the healthcare big data for quality medical services. This article provides a systematic review study on healthcare big data based on the systematic literature review (SLR) protocol. In particular, the present study highlights some valuable research aspects on healthcare big data, evaluating 34 journal articles (between 2015 and 2019) according to the defined inclusion-exclusion criteria. More specifically, the present study focuses to determine the extent of healthcare big data analytics together with its applications and challenges in healthcare adoption. Besides, the article discusses big data produced by these healthcare systems, big data characteristics, and various issues in dealing with big data, as well as how big data analytics contributes to achieve a meaningful insight on these data set. In short, the article summarizes the existing literature based on healthcare big data, and it also helps the researchers with a foundation for future study in healthcare contexts.