Details

Autor(en) / Beteiligte

• Lam, Tommy Tsan-Yuk
• Jia, Na
• Zhang, Ya-Wei
• Shum, Marcus Ho-Hin
• Jiang, Jia-Fu
• Zhu, Hua-Chen
• Tong, Yi-Gang
• Shi, Yong-Xia
• Ni, Xue-Bing
• Liao, Yun-Shi
• Li, Wen-Juan
• Jiang, Bao-Gui
• Wei, Wei
• Yuan, Ting-Ting
• Zheng, Kui
• Cui, Xiao-Ming
• Li, Jie
• Pei, Guang-Qian
• Qiang, Xin
• Cheung, William Yiu-Man
• Li, Lian-Feng
• Sun, Fang-Fang
• Qin, Si
• Huang, Ji-Cheng
• Leung, Gabriel M.
• Holmes, Edward C.
• Hu, Yan-Ling
• Guan, Yi
• Cao, Wu-Chun

Titel

Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins

Ist Teil von

• Nature (London), 2020-07, Vol.583 (7815), p.282-285

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• The ongoing outbreak of viral pneumonia in China and across the world is associated with a new coronavirus, SARS-CoV-2 1 . This outbreak has been tentatively associated with a seafood market in Wuhan, China, where the sale of wild animals may be the source of zoonotic infection 2 . Although bats are probable reservoir hosts for SARS-CoV-2, the identity of any intermediate host that may have facilitated transfer to humans is unknown. Here we report the identification of SARS-CoV-2-related coronaviruses in Malayan pangolins ( Manis javanica ) seized in anti-smuggling operations in southern China. Metagenomic sequencing identified pangolin-associated coronaviruses that belong to two sub-lineages of SARS-CoV-2-related coronaviruses, including one that exhibits strong similarity in the receptor-binding domain to SARS-CoV-2. The discovery of multiple lineages of pangolin coronavirus and their similarity to SARS-CoV-2 suggests that pangolins should be considered as possible hosts in the emergence of new coronaviruses and should be removed from wet markets to prevent zoonotic transmission. SARS-CoV-2-related coronaviruses are identified in Malayan pangolins ( Manis javanica ); these pangolin-associated coronaviruses belonged to two sub-lineages of SARS-CoV-2-related coronaviruses, including one that exhibits strong similarity in the receptor-binding domain to SARS-CoV-2.