Details

Autor(en) / Beteiligte

• Bansal, Kuldeep K
• Rosenholm, Jessica M

Titel

Synthetic polymers from renewable feedstocks: an alternative to fossil-based materials in biomedical applications

Ist Teil von

• Therapeutic delivery, 2020-05, Vol.11 (5), p.297-300

Ort / Verlag

England: Newlands Press Ltd

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• [...]today’s research and development in polymer-based drug delivery is mainly focused on utilizing polymers derived from renewable resources. [...]in this commentary, we will shed light on the status of renewable polymers in drug-delivery applications and their ability to replace fossil-based polymers. At present, PLA and/or PGA based materials are the only widely explored renewable materials and abundant literature is available discussing their properties and applications (3,4). [...]with the help of this article, we would like to bring up polymers other than PLA and PGA, which are relatively less explored but could still readily act as alternative materials to fossil-based polymers in biomedical applications. [...]the crystallinity of PDL polymers can be tuned by copolymerizing with the highly crystalline renewable monomer ω-pentadecalactone, which is an excellent example of tunability of a synthetic renewable polymer, to control drug release rate. [...]as a polyester, PDL can degrade into small-chained species at physiologically relevant conditions (6,7). Considering diminution of nonrenewable resources, escalation in the price of petroleum-based products will not come as a surprise. [...]it is essential that researchers focus more on finding sustainable and economical alternatives of fossil-based materials used in pharmaceutical industries, ranging from excipients to polymeric nanomedicines.