Details

Autor(en) / Beteiligte

• Merlano, Marco Carlo
• Denaro, Nerina
• Vivenza, Daniela
• Monteverde, Martino
• Russi, Elvio
• Lerda, Walter
• Comino, Alberto
• Lo Nigro, Cristiana

Titel

P16 Cutoff in Head and Neck Squamous Cell Carcinoma: Correlation between Tumor and Patient Characteristics and Outcome

Ist Teil von

• The International journal of biological markers, 2016-01, Vol.31 (1), p.44-52

Ort / Verlag

London, England: SAGE Publications

Erscheinungsjahr

2016

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Background p16 has been indicated as a suitable surrogate biomarker of HPV infection. The prognosis of p16-positive oropharynx tumors (OTs) of squamous cell carcinoma (SCC) histology is better than that of p16-negative tumors. Methods We analyzed 209 samples of head and neck SCC to establish a predictive cutoff for p16 and determine the role of p16 positivity in OTs versus non-OTs. We compared the outcomes of tumors harboring any percentage of p16-positive cells (≥1%) with those of p16-negative OTs. We then considered 3 cutoffs (10%, 50% and 70% positive cells) to evaluate the outcome of OTs/non-OTs with similar p16 expression and p16-positive versus p16-negative tumors stratified by patient age. Results p16-negative tumors among OTs and non-OTs were 29% and 49%, respectively (p = 0.0054). The cumulative distribution showed that the positive values were located around 2 focus points: 2% and 96%. Subgroup analysis showed that only OTs occurred in young patients (aged <65 years) and that there was a ≥70% gain in survival in cases with p16-positive cells. Conclusions p16 positivity influences outcome only in young patients and OTs (p = 0.048).