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Synthesis, Structure, and Anticancer Activity of Symmetrical and Non-symmetrical Silver(I)-N-Heterocyclic Carbene Complexes
Ist Teil von
Applied biochemistry and biotechnology, 2020-07, Vol.191 (3), p.1171-1189
Ort / Verlag
New York: Springer US
Erscheinungsjahr
2020
Link zum Volltext
Quelle
springer (창간호~2014)
Beschreibungen/Notizen
Synthesis and anticancer studies of three symmetrically and non-symmetrically substituted silver(I)-
N
-Heterocyclic carbene complexes of type [(NHC)
2
-Ag]PF
6
(
7–9
) and their respective (ligands) benzimidazolium salts (
4–6
) are described herein. Compound
5
and Ag-NHC-complex
7
were characterized by the single crystal X-ray diffraction technique. Structural studies for
7
showed that the silver(I) center has linear C-Ag-C coordination geometry (180.00(10)
o
). Other azolium and Ag-NHC analogues were confirmed by H
1
and C
13
-NMR spectroscopy. The synthesized analogues were biologically characterized for in vitro anticancer activity against three cancer cell lines including human colorectal cancer (HCT 116), breast cancer (MCF-7), and erythromyeloblastoid leukemia (K-562) cell lines and in terms of in vivo acute oral toxicity (IAOT) in view of agility and body weight of female rats. In vitro anticancer activity showed the values of IC
50
in range 0.31–17.9 μM in case of K-562 and HCT-116 cancer cell lines and 15.1–35.2 μM in case of MCF-7 while taking commercially known anticancer agents 5-fluorouracil, tamoxifen, and betulinic acid which have IC
50
values 5.2, 5.5, and 17.0 μM, respectively. In vivo study revealed vigor and agility of all test animals which explores the biocompatibility and non-toxicity of the test analogues.