Chemistry, an Asian journal, 2020-05, Vol.15 (10), p.1536-1539
2020
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Visible‐Light‐Promoted Selenylative Spirocyclization of Indolyl‐ynones toward the Formation of 3‐Selenospiroindolenine Anticancer Agents
- Ist Teil von
- Chemistry, an Asian journal, 2020-05, Vol.15 (10), p.1536-1539
- Ort / Verlag
- Germany: Wiley Subscription Services, Inc
- Erscheinungsjahr
- 2020
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- A metal‐free and efficient visible‐light‐induced spirocyclization of indolyl‐ynones with diselenides at room temperature under air atmosphere to prepare 3‐selenospiroindolenines in moderate to good yields has been developed. The resulting products were tested for in vitro anticancer activity by MTT assay, and compounds 3 c and 3 e showed potent cancer cell‐growth inhibition activities. A visible‐light‐induced spirocyclization of indolyl‐ynones with diselenides was developed, providing selenospiroindolenines as products. Furthermore, the obtained products showed potent cancer cell‐growth inhibition activities.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1861-4728eISSN: 1861-471XDOI: 10.1002/asia.202000298Titel-ID: cdi_proquest_journals_2402821040
- Format
- –
- Schlagworte
- 3-selenospiroindolenines, Aldehydes - chemistry, anticancer agents, Anticancer properties, Antineoplastic Agents - chemical synthesis, Antineoplastic Agents - chemistry, Antineoplastic Agents - pharmacology, Cancer, Cell Line, Tumor, Cell Proliferation - drug effects, Chemistry, Cyclization, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, HeLa Cells, Humans, Indoles - chemical synthesis, Indoles - chemistry, Indoles - pharmacology, Light, Molecular Conformation, Organoselenium Compounds - chemical synthesis, Organoselenium Compounds - chemistry, Organoselenium Compounds - pharmacology, photocatalyst-free, Room temperature, Selenides, Spiro Compounds - chemical synthesis, Spiro Compounds - chemistry, Spiro Compounds - pharmacology, spirocyclization, Structure-Activity Relationship, visible-light initiation