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Visible‐Light‐Promoted Selenylative Spirocyclization of Indolyl‐ynones toward the Formation of 3‐Selenospiroindolenine Anticancer Agents
Ist Teil von
Chemistry, an Asian journal, 2020-05, Vol.15 (10), p.1536-1539
Ort / Verlag
Germany: Wiley Subscription Services, Inc
Erscheinungsjahr
2020
Quelle
MEDLINE
Beschreibungen/Notizen
A metal‐free and efficient visible‐light‐induced spirocyclization of indolyl‐ynones with diselenides at room temperature under air atmosphere to prepare 3‐selenospiroindolenines in moderate to good yields has been developed. The resulting products were tested for in vitro anticancer activity by MTT assay, and compounds 3 c and 3 e showed potent cancer cell‐growth inhibition activities.
A visible‐light‐induced spirocyclization of indolyl‐ynones with diselenides was developed, providing selenospiroindolenines as products. Furthermore, the obtained products showed potent cancer cell‐growth inhibition activities.