Details

Autor(en) / Beteiligte

• Azizollahi, Hamid
• Pérez‐Gómez, Marta
• Mehta, Vaibhav P.
• García‐López, José‐Antonio

Titel

Synthesis of [3.4]‐Spirooxindoles through Cascade Carbopalladation of Skipped Dienes

Ist Teil von

• Advanced synthesis & catalysis, 2020-04, Vol.362 (9), p.1899-1904

Ort / Verlag

Heidelberg: Wiley Subscription Services, Inc

Erscheinungsjahr

2020

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• A synthetic route to [3.4]‐spirooxindoles based on cascade carbopalladation reactions of 1,4‐dienes is described. While carbopalladation of alkenes have been used to access mainly [4.4]‐ or [4.5]‐spirocycles, 4‐exo‐trig carbopalladation has not been yet applied to the synthesis of relevant [3.4]‐spirooxindole scaffolds bearing a cyclobutyl ring. In addition, the cascade reaction generates an exocyclic double bond that can serve as a platform to further diversify the substitution pattern of the spirooxindole nuclei.