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Cardiac Noradrenaline Turnover and Heat Shock Protein 27 Phosphorylation in Dyskinetic Monkeys
Movement disorders, 2020-04, Vol.35 (4), p.698-703
Almela, Pilar
Cuenca‐Bermejo, Lorena
Yuste, José E.
Estrada, Cristina
Pablos, Vicente
Bautista‐Hernández, Víctor
Fernández‐Villalba, Emiliano
Laorden, María‐Luisa
Herrero, María‐Trinidad
2020
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Almela, Pilar
Cuenca‐Bermejo, Lorena
Yuste, José E.
Estrada, Cristina
Pablos, Vicente
Bautista‐Hernández, Víctor
Fernández‐Villalba, Emiliano
Laorden, María‐Luisa
Herrero, María‐Trinidad
Titel
Cardiac Noradrenaline Turnover and Heat Shock Protein 27 Phosphorylation in Dyskinetic Monkeys
Ist Teil von
Movement disorders, 2020-04, Vol.35 (4), p.698-703
Ort / Verlag
Hoboken, USA: John Wiley & Sons, Inc
Erscheinungsjahr
2020
Quelle
MEDLINE
Beschreibungen/Notizen
Background Autonomic dysfunction is a well‐known dominant symptom in the advanced stages of Parkinson's disease. However, the role of cardiac sympathetic nerves still needs to be elucidated. Objectives To evaluate cardiac sympathetic response in Parkinsonian and dyskinetic monkeys. Methods Adult male monkeys were divided into 1 of the following 3 groups: controls, 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine–treated monkeys, and 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine+levodopa–treated animals. Noradrenaline, its metabolite normetanephrine, and phospho‐Heat shock proten 27 (p‐Hsp27) at serine 82 levels were analyzed in the left and right ventricles of the heart. Tyrosine hydroxylase immunohistochemistry was performed in the ventral mesencephalon. Results The results were the following: (1) 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine intoxication significantly increased normetanephrine levels and decreased noradrenaline turnover in the right ventricle without changes in the left ventricle; however, (2) levodopa treatment decreased noradrenaline levels and enhanced the normetanephrine/noradrenaline ratio in parallel with a very significant increase of Hsp27 activity in both ventricles. Conclusions Levodopa treatment could induce protective cardiac effects through the increased Hsp27 activity. © 2019 International Parkinson and Movement Disorder Society
Sprache
Englisch
Identifikatoren
ISSN: 0885-3185
eISSN: 1531-8257
DOI: 10.1002/mds.27958
Titel-ID: cdi_proquest_journals_2390686749
Format
–
Schlagworte
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
,
Animals
,
Basal ganglia
,
Central nervous system diseases
,
Dyskinesias - metabolism
,
Heart diseases
,
Heat shock proteins
,
Hsp27
,
HSP27 Heat-Shock Proteins
,
Hsp27 protein
,
Hydroxylase
,
Immunohistochemistry
,
Intoxication
,
Levodopa
,
l‐dopa
,
Macaca fascicularis
,
Male
,
Mesencephalon
,
Metabolites
,
Movement disorders
,
NA turnover
,
Neurodegenerative diseases
,
Norepinephrine
,
Parkinson's disease
,
Phosphorylation
,
Protein turnover
,
Serine
,
Sympathetic nerves
,
Tyrosine 3-monooxygenase
,
Tyrosine 3-Monooxygenase - metabolism
,
Ventricle
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