Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Journal of inorganic and organometallic polymers and materials, 2020-05, Vol.30 (5), p.1503-1518
Ort / Verlag
New York: Springer US
Erscheinungsjahr
2020
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Polyamidoamine drug conjugates containing ferrocene and platinum analogues were prepared in this study. Fourier transform infrared spectra confirmed the successful isolation of the conjugates with signals at 3300 cm
−1
for amide N–H stretch and for C=O stretch at 1655–1635 cm
−1
resulting from the conjugation of 4-ferrocenylketobutanoic acid. The polyamidoamine drug conjugate particle size was 247.1 nm and 258.3 nm suggesting their ability to exhibit in vitro phagocytosis. The average particle charges were 29 and 30.2, which was indicative of good stability and the capability to resist aggregation. In vitro cytotoxicity studies further revealed that the conjugates
1–5
did not exhibit cytotoxicity towards the normal cell lines (EA.hy926) whereas high cytotoxic activity was noted against the cancer cell lines (MCF-7 and MDA-MB-231) indicating selectivity towards cancer cell lines. Fc-PDA acted as a potentiating agent when incorporated together with DACH PtCl
2
in the polymers, resulting in a good inhibitory effect in vitro. However, when combining Fc-PDA with K
2
PtCl
4
in the polymer, an antagonistic effect was noted. The current findings implicate that the prepared conjugates hold the potential as therapeutics for the treatment of breast cancer. Further research is required to confirm this.