Details

Autor(en) / Beteiligte

• Hayden, Anna R.
• Lee, Derrick G.
• Villa, Diego
• Gerrie, Alina S.
• Scott, David W.
• Slack, Graham W.
• Sehn, Laurie H.
• Connors, Joseph M.
• Savage, Kerry J.

Titel

Validation of a simplified international prognostic score (IPS‐3) in patients with advanced‐stage classic Hodgkin lymphoma

Ist Teil von

• British journal of haematology, 2020-04, Vol.189 (1), p.122-127

Ort / Verlag

England: Blackwell Publishing Ltd

Erscheinungsjahr

2020

Quelle

Access via Wiley Online Library

Beschreibungen/Notizen

• Summary A novel prognostic score (IPS‐3), comprised of only three of the seven IPS‐7 indicators (age ≥45, stage IV, haemoglobin <105 g/l), was recently proposed as a simplified model for advanced‐stage classic Hodgkin lymphoma (cHL). We aimed to validate this model in advanced‐stage cHL patients treated with doxorubicin, bleomycin, vinblastine, dacarbazine (ABVD) in British Columbia. The estimated five‐year freedom from progression (FFP) for scores of 0, 1, 2 and 3 were very similar to the original report at 84%, 76%, 72% and 68% respectively. The IPS‐3 score is highly reproducible in this independent dataset and its simplicity makes it appealing for everyday clinical practice.