Biological and Pharmaceutical Bulletin, 2020/03/01, Vol.43(3), pp.409-417
2020
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- Autor(en) / Beteiligte
- Titel
- Neuroprotective Effects of Limonene (+) against Aβ42-Induced Neurotoxicity in a Drosophila Model of Alzheimer’s Disease
- Ist Teil von
- Biological and Pharmaceutical Bulletin, 2020/03/01, Vol.43(3), pp.409-417
- Ort / Verlag
- Japan: The Pharmaceutical Society of Japan
- Erscheinungsjahr
- 2020
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Forest bathing is suggested to have beneficial effects on various aspects of human health. Terpenes, isoprene based-phytochemicals emitted from trees, are largely responsible for these beneficial effects of forest bathing. Although the therapeutic effects of terpenes on various diseases have been revealed, their effects on neuronal health have not yet been studied in detail. Here, we screened 16 terpenes that are the main components of Korean forests using Drosophila Alzheimer’s disease (AD) models to identify which terpenes have neuroprotective effects. Six out of the 16 terpenes, ρ-cymene, limonene (+), limonene (−), linalool, α-pinene (+), and β-pinene (−), partially suppressed the beta amyloid 42 (Aβ42)-induced rough eye phenotype when fed to Aβ42-expressing flies. Among them, limonene (+) restored the decreased survival of flies expressing Aβ42 in neurons during development. Limonene (+) treatment did not affect Aβ42 accumulation and aggregation, but did cause to decrease cell death, reactive oxygen species levels, extracellular signal-regulated kinase phosphorylation, and inflammation in the brains or the eye imaginal discs of Aβ42-expressing flies. This neuroprotective effect of limonene (+) was not associated with autophagic activity. Our results suggest that limonene (+) has a neuroprotective function against the neurotoxicity of Aβ42 and, thus, is a possible therapeutic reagent for AD.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0918-6158eISSN: 1347-5215DOI: 10.1248/bpb.b19-00495Titel-ID: cdi_proquest_journals_2369562719
- Format
- –
- Schlagworte
- Alzheimer Disease - drug therapy, Alzheimer Disease - metabolism, Alzheimer's disease, Amyloid beta-Peptides - toxicity, amyloid β42, Animals, Animals, Genetically Modified, Autophagy - drug effects, Brain - metabolism, Cell death, Disease Models, Animal, Drosophila, Drosophila melanogaster, Extracellular signal-regulated kinase, Imaginal discs, Insects, Isoprene, Limonene, Limonene - pharmacology, Linalool, MAP Kinase Signaling System - drug effects, Neurodegenerative diseases, Neuroglia - drug effects, Neuroprotection, Neuroprotective Agents - pharmacology, Neurotoxicity, p-Cymene, Peptide Fragments - toxicity, Phenotypes, Phosphorylation, Phosphorylation - drug effects, Reactive oxygen species, Reactive Oxygen Species - metabolism, Survival, terpene, Terpenes, Terpenes - pharmacology, α-Pinene, β-Amyloid