American journal of epidemiology, 2008-09, Vol.168 (5), p.532-540
2008
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Details
- Autor(en) / Beteiligte
- Titel
- Gender Differences in HIV Progression to AIDS and Death in Industrialized Countries: Slower Disease Progression Following HIV Seroconversion in Women
- Ist Teil von
- American journal of epidemiology, 2008-09, Vol.168 (5), p.532-540
- Ort / Verlag
- Cary, NC: Oxford University Press
- Erscheinungsjahr
- 2008
- Quelle
- Oxford Journals 2020 Medicine
- Beschreibungen/Notizen
- To evaluate sex differences in human immunodeficiency virus (HIV) disease progression before (pre-1997) and after (1997–2006) introduction of highly active antiretroviral therapy, the authors used data from a collaboration of 23 HIV seroconverter cohort studies from Europe, Australia, and Canada restricted to the 6,923 seroconverters infected through injecting drug use and sex between men and women. Within a competing risk framework, they used Cox proportional hazards models allowing for late entry to evaluate sex differences in time from HIV seroconversion to death, to acquired immunodeficiency syndrome (AIDS), and to each first AIDS-defining disease and death without AIDS. While no significant sex differences were found before 1997, from 1997 onward, women had a lower risk of AIDS (adjusted cumulative relative risk (aCRR) = 0.76, 95% confidence interval (CI): 0.63, 0.90) and death (adjusted hazard ratio = 0.68, 95% CI: 0.56, 0.82) than men did. Compared with men, women also had lower risks of AIDS dementia complex (aCRR = 0.23, 95% CI: 0.07, 0.74), tuberculosis (aCRR = 0.60, 95% CI: 0.39, 0.92), Kaposi's sarcoma (aCRR = 0.27, 95% CI: 0.07, 0.99), lymphomas (aCRR = 0.47, 95% CI: 0.23, 0.96), and death without AIDS (aCRR = 0.74, 95% CI: 0.56, 0.98). Sex differences in HIV disease progression have become larger and statistically significant in the era of highly active antiretroviral therapy, supporting a stronger impact of health interventions among women.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0002-9262eISSN: 1476-6256DOI: 10.1093/aje/kwn179Titel-ID: cdi_proquest_journals_235855104
- Format
- –
- Schlagworte
- acquired immunodeficiency syndrome, Acquired Immunodeficiency Syndrome - drug therapy, Acquired Immunodeficiency Syndrome - epidemiology, Adult, AIDS-Related Opportunistic Infections - epidemiology, Analysis. Health state, Antiretroviral drugs, antiretroviral therapy, Antiretroviral Therapy, Highly Active - methods, Australia - epidemiology, Biological and medical sciences, Canada - epidemiology, Cohort Studies, Confidence Intervals, death, Developed Countries - statistics & numerical data, disease progression, Epidemiology, Europe - epidemiology, Female, Gender differences, General aspects, highly active, HIV, HIV Infections - complications, HIV Infections - diagnosis, HIV Infections - drug therapy, HIV Infections - epidemiology, HIV Infections - mortality, HIV Seropositivity, HIV-1 - isolation & purification, Human immunodeficiency virus, Human viral diseases, Humans, Infectious diseases, Male, Medical prognosis, Medical sciences, Odds Ratio, Proportional Hazards Models, Public health. Hygiene, Public health. Hygiene-occupational medicine, Risk, Risk factors, sex, Sex Factors, Substance Abuse, Intravenous - complications, Viral diseases, Viral diseases of the lymphoid tissue and the blood. Aids