Organic Chemistry Frontiers, 2020-02, Vol.7 (3), p.609-616
2020
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- Autor(en) / Beteiligte
- Titel
- Catalytic asymmetric 1,4-type Friedel–Crafts (hetero)arylations of 1-azadienes: the highly enantioselective syntheses of chiral hetero-triarylmethanes
- Ist Teil von
- Organic Chemistry Frontiers, 2020-02, Vol.7 (3), p.609-616
- Ort / Verlag
- London: Royal Society of Chemistry
- Erscheinungsjahr
- 2020
- Quelle
- Alma/SFX Local Collection
- Beschreibungen/Notizen
- Direct enantioselective Michael-type Friedel–Crafts arylations and heteroarylations of s- cis 1-azadienes were achieved by applying chiral bifunctional tertiary amine-urea catalysts when using 2-naphthols as the nucleophiles, and phosphoric acid catalysts when using indoles as the nucleophiles. These two catalytic protocols efficiently enabled access to a diverse variety of important benzofuran-containing hetero-triarylmethanes in up to 98% yield and with 99.5 : 0.5 er.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2052-4129, 2052-4110eISSN: 2052-4129, 2052-4110DOI: 10.1039/C9QO01391ATitel-ID: cdi_proquest_journals_2350887739
- Format
- –
- Schlagworte
- Benzofuran, Catalysts, Crystal structure, Crystallography, Crystals, Enantiomers, Friedel-Crafts reaction, High-performance liquid chromatography, Indoles, Liquid chromatography, NMR, Nuclear magnetic resonance, Nucleophiles, Organic chemistry, Phosphoric acid, Single crystals, Structural analysis, Urea