Details

Autor(en) / Beteiligte

• Butler, Santino S.
• Muralidhar, Vinayak
• Zhao, Shuang G.
• Sanford, Nina N.
• Franco, Idalid
• Fullerton, Zoe H.
• Chavez, Janice
• D’Amico, Anthony V.
• Feng, Felix Y.
• Rebbeck, Timothy R.
• Nguyen, Paul L.
• Mahal, Brandon A.

Titel

Prostate cancer incidence across stage, NCCN risk groups, and age before and after USPSTF Grade D recommendations against prostate‐specific antigen screening in 2012

Ist Teil von

• Cancer, 2020-02, Vol.126 (4), p.717-724

Ort / Verlag

United States: Wiley Subscription Services, Inc

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• Background We sought to determine the extent to which US Preventive Services Task Force (USPSTF) 2012 Grade D recommendations against prostate‐specific antigen screening may have impacted recent prostate cancer disease incidence patterns in the United States across stage, National Comprehensive Cancer Network (NCCN) risk groups, and age groups. Methods SEER*Stat version 8.3.4 was used to calculate annual prostate cancer incidence rates from 2010 to 2015 for men aged ≥50 years according to American Joint Committee on Cancer stage at diagnosis (localized vs metastatic), NCCN risk group (low vs unfavorable [intermediate or high‐risk]), and age group (50‐74 years vs ≥75 years). Age‐adjusted incidences per 100,000 persons with corresponding year‐by‐year incidence ratios (IRs) were calculated using the 2000 US Census population. Results From 2010 to 2015, the incidence (per 100,000 persons) of localized prostate cancer decreased from 195.4 to 131.9 (Ptrend < .001) and from 189.0 to 123.4 (Ptrend < .001) among men aged 50‐74 and ≥75 years, respectively. The largest relative year‐by‐year decline occurred between 2011 and 2012 in NCCN low‐risk disease (IR, 0.77 [0.75–0.79, P < .0001] and IR 0.68 [0.62–0.74, P < .0001] for men aged 50‐74 and ≥75 years, respectively). From 2010‐2015, the incidence of metastatic disease increased from 6.2 to 7.1 (Ptrend < .001) and from 16.8 to 22.6 (Ptrend < .001) among men aged 50‐74 and ≥75 years, respectively. Conclusions This report illustrates recent prostate cancer “reverse migration” away from indolent disease and toward more aggressive disease beginning in 2012. The incidence of localized disease declined across age groups from 2012 to 2015, with the greatest relative declines occurring in low‐risk disease. Additionally, the incidence of distant metastatic disease increased gradually throughout the study period. This report illustrates a recent “reverse migration” of prostate cancer away from indolent disease and toward more aggressive disease beginning in 2012. The incidence of localized disease has declined across age groups from 2012 to 2015—with the greatest relative declines occurring in low‐risk disease—while the incidence of distant metastatic disease has gradually increased.