Details

Autor(en) / Beteiligte

• Guo, Tiantian
• Song, Yiming
• Lu, Yinghui
• Li, Guolin
• Liu, Tian
• Han, Wenrong
• Song, Weiguo
• Yang, Chuncheng
• Li, Fahui
• Liu, Qingchao

Titel

Total synthesis and anticancer activity of the natural oleanolic acid bidesmoside saponin, albidoside A, isolated from the roots of Acacia albida

Ist Teil von

• Journal of chemical research, 2020-01, Vol.44 (1-2), p.42-49

Ort / Verlag

London, England: SAGE Publications

Erscheinungsjahr

2020

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The first synthesis of a natural triterpenoid saponin bearing N-acetylglucosamine, albidoside A, which is isolated from the roots of Acacia albida, is concisely achieved in a convergent strategy. Preliminary pharmacological research shows anticancer activity against HL-60, MCF-7, MDA-MB-231, Hep-2, and Hela cell lines. In particular, it exhibited good selectivity, which is five times more cytotoxic toward Hep-2 cells (IC50 = 8.91 μM) than the Hela cell line.