Details

Autor(en) / Beteiligte

• Zribi, R.
• Maalej, R.
• Messina, E.
• Gillibert, R.
• Donato, M.G.
• Maragò, O.M.
• Gucciardi, P.G.
• Leonardi, S.G.
• Neri, G.

Titel

Exfoliated 2D-MoS2 nanosheets on carbon and gold screen printed electrodes for enzyme-free electrochemical sensing of tyrosine

Ist Teil von

• Sensors and actuators. B, Chemical, 2020-01, Vol.303, p.127229, Article 127229

Ort / Verlag

Lausanne: Elsevier B.V

Erscheinungsjahr

2020

Quelle

ScienceDirect

Beschreibungen/Notizen

• •Exfoliated two-dimensional molybdenum disulphide nanosheets (2D-MoS2) have been prepared.•A enzyme-free 2D-MoS2 electrochemical sensor for the determination of tyrosine (Tyr) has been proposed for the first time.•2D-MoS2-SPCE electrode showed good performances, reaching a maximum sensitivity to Tyr of 1580 μA mM−1 cm−2.•A voltammetric method by using 2D-MoS2-SPCE electrode provided detection of Tyr in a real food integrator sample. We demonstrate a simple enzyme-free electrochemical sensor for tyrosine (Tyr) detection, based on the enhanced catalytical activity of two-dimensional molybdenum disulphide nanosheets (2D-MoS2), prepared by liquid phase exfoliation and deposited on commercial screen-printed carbon and gold electrodes (SPE). We first evaluate the electrochemical performances of the sensor by cyclic voltammetry (CV) in phosphate buffer solutions (PBS; pH = 7) as a function of the chemical nature and microscale texture of the working electrode, as well as the operating potential window. Results show that the modified-carbon (2D-MoS2-SPCE) and gold (2D-MoS2-SPAuE) electrodes display various anodic and cathodic peaks, whose potential and intensity depend on the potential window, electrode nature and 2D-MoS2 loading. 2D-MoS2 SPE electrodes are finally tested for voltammetric and amperometric detection of tyrosine. We show that 2D-MoS2-SPCE provide the best results, reaching a maximum sensitivity of 1580 μA mM−1 cm−2 and a limit of detection (LOD) of 0.5 μM computed at a S/N = 3. The proposed method shows satisfactory results also for the detection of tyrosine in a real food integrator sample. To our best knowledge, this is the first report demonstrating the use of 2D-MoS2 for the electrochemical determination of tyrosine.