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Taylor & Francis Journals Auto-Holdings Collection
Beschreibungen/Notizen
[...]personalized risk-benefit models to select the most appropriate of apparently equal options would be extremely useful. [...]some authors report that phenotyping, which is based on measurement of DPYD activity in peripheral blood mononuclear cells can minimize life-threatening toxicity (6-8). [...]diminished TYMS expression has been related to a higher risk of toxicity. Knowledge of capecitabine pharmacogenetics and its role in toxicity remains insufficient. [...]alternative approaches are necessary to find new biomarkers that would improve current predictive models.