Details

Autor(en) / Beteiligte

• Moskalenko, A. V.

Titel

Nonlinear effects of lidocaine on polymorphism of ventricular arrhythmias

Ist Teil von

• Biophysics (Oxford), 2009-02, Vol.54 (1), p.47-50

Ort / Verlag

Dordrecht: SP MAIK Nauka/Interperiodica

Erscheinungsjahr

2009

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• For the first time experimental evidence for the nonlinear dependence of the antiarrhythmic effect of the Na-channel blocker on its concentration was obtained. The experiments were carried out with the use of a preparation of the mammalian heart wall. As a blocker, lidocaine was used. It was found that conventional “antiarrhythmic” concentrations of lidocaine made ventricular tachycardias indeed more monomorphic, but at lower concentrations lidocaine unexpectedly increased the probability for the ventricular tachycardias to appear more polymorphic. The biophysical reason of this phenomenon is discussed.