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BibTeX
Comparative Analysis of the Developmental Toxicity in Xenopus laevis and Danio rerio Induced by Al2O3 Nanoparticle Exposure
Environmental toxicology and chemistry, 2019-12, Vol.38 (12), p.2672-2681
Ismail, Tayaba
Lee, Hyun‐Kyung
Kim, Chowon
Kim, Youni
Lee, Hongchan
Kim, Jun‐Hyeong
Kwon, Song
Huh, Tae‐Lin
Khang, Dongwoo
Kim, Sang‐Hyun
Choi, Sun‐Cheol
Lee, Hyun‐Shik
2019
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Ismail, Tayaba
Lee, Hyun‐Kyung
Kim, Chowon
Kim, Youni
Lee, Hongchan
Kim, Jun‐Hyeong
Kwon, Song
Huh, Tae‐Lin
Khang, Dongwoo
Kim, Sang‐Hyun
Choi, Sun‐Cheol
Lee, Hyun‐Shik
Titel
Comparative Analysis of the Developmental Toxicity in Xenopus laevis and Danio rerio Induced by Al2O3 Nanoparticle Exposure
Ist Teil von
Environmental toxicology and chemistry, 2019-12, Vol.38 (12), p.2672-2681
Ort / Verlag
Oxford: Blackwell Publishing Ltd
Erscheinungsjahr
2019
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Engineered aluminum oxide nanoparticles (Al2O3 NPs) having high‐grade thermal stability and water‐dispersion properties are extensively used in different industries and personal care products. Toxicological response evaluation of these NPs is indispensable in assessing the health risks and exposure limits because of their industrial disposal into the aquatic environment. We assessed and compared the developmental toxicity of Al2O3 NPs in Xenopus laevis and Danio rerio over a period of 96 h using the frog embryo teratogenic assay Xenopus and a fish embryo toxicity assay. Engineered Al2O3 NP exposure produced dose‐dependent embryonic mortality and decreased the embryo length, indicating a negative effect on growth. Moreover, Al2O3 NPs induced various malformations, such as small head size, a bent/deformed axis, edema, and gut malformation, dose‐dependently and altered the expression of heart‐ and liver‐specific genes in both X. laevis and D. rerio, as revealed by whole‐mount in‐situ hybridization and reverse transcriptase polymerase chain reaction. In conclusion, the toxicological data suggest that Al2O3 NPs are developmentally toxic and teratogenic and negatively affect the embryonic development of X. laevis and D. rerio. Our study can serve as a model for the toxicological evaluation of nanomaterial exposure on vertebrate development that is critical to ensure human and environmental safety. Environ Toxicol Chem 2019;38:2672–2681. © 2019 SETAC
Sprache
Englisch
Identifikatoren
ISSN: 0730-7268
eISSN: 1552-8618
DOI: 10.1002/etc.4584
Titel-ID: cdi_proquest_journals_2316850879
Format
–
Schlagworte
Al2O3 nanoparticles
,
Aluminum
,
Aluminum oxide
,
Aquatic environment
,
Chemical wastewater
,
Comparative analysis
,
Consumer products
,
Danio rerio
,
Edema
,
Embryogenesis
,
Embryonic development
,
Embryonic growth stage
,
Embryos
,
Evaluation
,
Exposure limits
,
Gene expression
,
Health risks
,
Heart
,
Hybridization
,
Nanomaterials
,
Nanoparticles
,
Polymerase chain reaction
,
RNA-directed DNA polymerase
,
Teratogenicity
,
Thermal stability
,
Toxicity
,
Toxicology
,
Vertebrates
,
Xenopus laevis
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