Details

Autor(en) / Beteiligte

• Zhang, Xiao-Lan
• Wei, Mei-Hong
• Chen, Jun-Min
• Liu, Xiao-Ling

Titel

One-pot synthesis of novel ether-linked diisoxazole derivatives via sequential O-propargylation and 1,3-dipolar cycloaddition from 2-bromohomoallylic alcohols

Ist Teil von

• Synthetic communications, 2020-01, Vol.50 (1), p.97-103

Ort / Verlag

Philadelphia: Taylor & Francis

Erscheinungsjahr

2020

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A simple and efficient, one-pot approach for the synthesis of ether-linked diisoxazole derivatives has been developed through sequential reactions, which includes O-propargylation of 2-bromohomoallylic alcohols with propargyl bromide in the presence of sodium hydride in THF, and 1,3-dipolar cycloaddition by the addition of hydroximinoyl chlorides and triethylamine. This protocol provides some advantages such as high regioselectivity, easy operation and good product yields with a wide scope of substrates under mild conditions.