Details

Autor(en) / Beteiligte

• Gruhn, Jennifer R
• Zielinska, Agata P
• Shukla, Vallari
• Blanshard, Robert
• Capalbo, Antonio
• Cimadomo, Danilo
• Nikiforov, Dmitry
• Chan, Andrew Chi-Ho
• Newnham, Louise J
• Vogel, Ivan
• Scarica, Catello
• Krapchev, Marta
• Taylor, Deborah
• Kristensen, Stine Gry
• Cheng, Junping
• Ernst, Erik
• Bjørn, Anne-Mette Bay
• Colmorn, Lotte Berdiin
• Blayney, Martyn
• Elder, Kay
• Liss, Joanna
• Hartshorne, Geraldine
• Grøndahl, Marie Louise
• Rienzi, Laura
• Ubaldi, Filippo
• McCoy, Rajiv
• Lukaszuk, Krzysztof
• Andersen, Claus Yding
• Schuh, Melina
• Hoffmann, Eva R

Titel

Chromosome errors in human eggs shape natural fertility over reproductive life span

Ist Teil von

• Science (American Association for the Advancement of Science), 2019-09, Vol.365 (6460), p.1466-1469

Ort / Verlag

United States: The American Association for the Advancement of Science

Erscheinungsjahr

2019

Quelle

Science Online_科学在线

Beschreibungen/Notizen

• Chromosome errors, or aneuploidy, affect an exceptionally high number of human conceptions, causing pregnancy loss and congenital disorders. Here, we have followed chromosome segregation in human oocytes from females aged 9 to 43 years and report that aneuploidy follows a U-curve. Specific segregation error types show different age dependencies, providing a quantitative explanation for the U-curve. Whole-chromosome nondisjunction events are preferentially associated with increased aneuploidy in young girls, whereas centromeric and more extensive cohesion loss limit fertility as women age. Our findings suggest that chromosomal errors originating in oocytes determine the curve of natural fertility in humans.