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Neurofilament light chain in serum of adolescent and adult SMA patients under treatment with nusinersen
Ist Teil von
Journal of neurology, 2020, Vol.267 (1), p.36-44
Ort / Verlag
Berlin/Heidelberg: Springer Berlin Heidelberg
Erscheinungsjahr
2020
Quelle
MEDLINE
Beschreibungen/Notizen
Objective
To determine the diagnostic and monitoring value of serum neurofilament light chain (NfL) in spinal muscular atrophy (SMA).
Methods
We measured serum NfL in 46 SMA patients at baseline and over 14 months of treatment with the antisense-oligonucleotide (ASO) nusinersen using the ultrasensitive single molecule array (Simoa) technology. Serum NfL levels of SMA patients were compared to controls and related to cerebrospinal fluid (CSF) NfL, blood-CSF barrier function quantified by the albumin blood/CSF ratio (Qalb) and motor scores (Hammersmith Functional Motor Scale Expanded, HFMSE; Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised, ALSFRS-R).
Results
Serum NfL levels of SMA patients were in the range of controls (
p
= 0.316) and did not correlate with CSF NfL (
ρ
= 0.302,
p
= 0.142) or Qalb (
ρ
= − 0.160,
p
= 0.293). During therapy, serum NfL levels were relatively stable with notable concentration changes in single SMA patients, however, within the control range. Higher NfL levels were associated with worse motor performance in SMA (baseline: HFMSE
ρ
= − 0.330,
p
= 0.025, ALSFRS-R
ρ
= − 0.403,
p
= 0.005; after 10 months: HFMSE
ρ
= − 0.525,
p
= 0.008, ALSFRS-R
ρ
= − 0.537,
p
= 0.007), but changes in motor scores did not correlate with changes in serum NfL.
Conclusion
Diagnostic and monitoring performance of serum NfL measurement seems to differ between SMA subtypes. Unlike to SMA type 1, in adolescent and adult SMA type 2 and 3 patients, neurodegeneration is not reflected by increased NfL levels and short-term therapeutic effects cannot be observed. Long-term follow-up has to be performed to see if even low levels of NfL might be good prognostic markers.