Details

Autor(en) / Beteiligte

• RADEMAKER, M. T
• CHARLES, C. J
• KOSOGLOU, T
• PROTTER, A. A
• ESPINER, E. A
• NICHOLLS, M. G
• RICHARDS, A. M

Titel

Clearance receptors and endopeptidase : equal role in natriuretic peptide metabolism in heart failure

Ist Teil von

• American journal of physiology. Heart and circulatory physiology, 1997-11, Vol.42 (5), p.H2372-H2379

Ort / Verlag

Bethesda, MD: American Physiological Society

Erscheinungsjahr

1997

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Rademaker et al investigated the effects of separate and combined endopeptidase inhibition and natriuretic peptide receptor C blockade on the clearance and bioactivity of atrial and brain natriuretic peptides in sheep with heart failure. They found that the enzymatic and receptor clearance pathways contribute equally to the metabolism of endogenous ANP and BNP.