Details

Autor(en) / Beteiligte

• Delabre, Rosemary M.
• Lapidus, Nathanael
• Salez, Nicolas
• Mansiaux, Yohann
• de Lamballerie, Xavier
• Carrat, Fabrice

Titel

Risk factors of pandemic influenza A / H 1 N 1 in a prospective household cohort in the general population: results from the C o P an F lu‐ F rance cohort

Ist Teil von

• Influenza and other respiratory viruses, 2015-01, Vol.9 (1), p.43-50

Ort / Verlag

Chichester: John Wiley & Sons, Inc

Erscheinungsjahr

2015

Link zum Volltext

Quelle

Wiley Online Library

Beschreibungen/Notizen

• Background The C o P an F lu‐ F rance household cohort was set up in 2009 to identify risk factors of infection by the pandemic A / H 1 N 1 ( H 1 N 1pdm09) virus in the general population. Objectives To investigate the determinants of infection during the 2010–2011 season, the first complete influenza season of study follow‐up for this cohort. Patients/Methods Pre‐ and post‐epidemic blood samples were collected for all subjects, and nasal swabs were obtained in all subjects from households where an influenza‐like illness was reported. Cases were defined as either a fourfold increase in the serological titer or a laboratory‐confirmed H 1 N 1pdm09 on a nasal swab, with either RT ‐ PCR or multiplex PCR . Risk factors for H 1 N 1pdm09 infections were explored, without any pre‐specified hypothesis, among 167 individual, collective and environmental covariates via generalized estimating equations modeling. We adopted a multimodel selection procedure to control for model selection uncertainty. Results This analysis is based on a sample size of 1121 subjects. The final multivariable model identified one risk factor (history of asthma, OR  = 2·17; 95% CI : 1·02–4·62) and three protective factors: pre‐epidemic serological titer ( OR  = 0·51 per doubling of the titer; 95% CI : 0·39–0·67), green tea consumption a minimum of two times a week ( OR  = 0·39; 95% CI : 0·18–0·84), and proportion of subjects in the household always covering their mouth while coughing/sneezing ( OR  = 0·93 per 10% increase; 95% CI : 0·86–1·00). Conclusion This exploratory study provides further support of previously reported risk factors and highlights the importance of collective protective behaviors in the household. Further analyses will be conducted to explore these findings.