Details

Autor(en) / Beteiligte

• Visness, Cynthia M.
• Gebretsadik, Tebeb
• Jackson, Daniel J.
• Biagini Myers, Jocelyn
• Havstad, Suzanne
• Lemanske, Robert F.
• Hartert, Tina V.
• Khurana Hershey, Gurjit K.
• Zoratti, Edward M.
• Martin, Lisa J.
• Miller, Rachel
• Gold, Diane R.
• Wright, Anne
• Stern, Debra A.
• Gern, James E.
• Johnson, Christine C.

Titel

Asthma as an outcome: Exploring multiple definitions of asthma across birth cohorts in the Environmental influences on Child Health Outcomes Children's Respiratory and Environmental Workgroup

Ist Teil von

• Journal of allergy and clinical immunology, 2019-09, Vol.144 (3), p.866-869.e4

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2019

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Cohorts with only questionnaire data available, such as the International Study of Asthma and Allergies in Childhood, rely on a parent-reported physician's diagnosis of asthma.1 Some studies have used lung function and airway hyperresponsiveness in their asthma definition criteria, whereas others have used reports of wheezing symptoms, asthma medication use, and health care data. Prevalence based on Definition 4 was the lowest of the 4 definitions for 1 cohort and the highest for 2 of the cohorts (Fig 1). [...]in addition to varying in inclusivity, the different definitions identified distinct subsets of children as having asthma (see Fig E1 in this article's Online Repository at www.jacionline.org). Ownby Childhood Allergy Study (CAS): D. Ownby,* C. C. Johnson, C. Joseph, E. Zoratti, G. Wegienka, S. Havstad, K. Woodcroft, E. Peterson, S. Hensley Alford, J. McCullough, C. Strauchman Boyer, S. Blocki, G. Birg, N. Akkerman, K. Wells, S. Zhang, C. Nicholas, A. Jones, G. StoufferAppendix CCCEH (n = 727) TCRS (n = 1246) IIS (n = 482) COAST (n = 259) URECA (n = 485) CCAAPS (n = 617) EHAAS (n = 438) WHEALS (n = 1258) CAS (n = 835) Race/ethnicity Hispanic 65% 26% 26% 3% 20% 1% 6% 7% 0% Non-Hispanic white 0% 59% 58% 87% 1% 66% 80% 26% 95% Non-Hispanic black 35% 2% 2% 4% 72% 16% 7% 63% 2% Other/mixed 0% 13% 14% 6% 7% 16% 8% 5% 4% Sex Male 48% 49% 48% 57% 51% 55% 54% 50% 49% Female 52% 51% 52% 43% 49% 45% 46% 50% 51% Mean (SD) age (y) at asthma assessment 7.0 (6.0-9.0) 6.2 (5.8-6.5) 5.1 (5.0-5.2) 6.0 (6.0-6.0) 7.0 (6.9-7.2) 6.8 (6.7-7.0) 7.0 (7.0-7.0) 10.2 (9.5-10.8) 6.7 (6.6-6.8) Type of eligibility∗ General General General Family history Family history Family history Family history General General Percentage with asthma in original cohort publication 31% 10% 12% 28% 29% 16% 8% 13% 10% Table I Demographic characteristics of participating CREW birth cohorts Cohort Cohort name Institution City Original cohort asthma definition Key eligibility criteria CCCEHE1 Columbia Center for Children's Environmental Health Columbia University Medical Center New York Parent-reported physician's diagnosis of asthma or report of wheeze or use of asthma medications in past year Women 18-35 years old who self-identified as African American or Dominican and had resided in northern Manhattan or the South Bronx for at least 1 year before pregnancy were included. URECAE5 Urban Environment and Childhood Asthma John's Hopkins University School of Medicine Boston University School of Medicine Columbia University Medical Center St Louis Children's Hospital Baltimore Boston New York St Louis (1) Parent-reported physician's diagnosis of asthma between age 4 and 7 years combined with asthma symptoms or use of asthma controller medication for 6 of the past 12 months; (2) methacholine PC20 ≤4 mg/mL or albuterol reversibility of FEV1 ≥ 10% combined with asthma symptoms or use of asthma controller medication for 6 of the past 12 months; or (3) report in the past 12 months of ≥2 wheezing episodes, ≥2 doctor's office visits for asthma/wheeze, ≥1 hospitalization for asthma/wheeze, or use of controller medications for 6 of the past 12 months.