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With the inhomogeneities of media taken into account, a generalized variable-coefficient Kadomtsev–Petviashvili (vcKP) equation is proposed to model nonlinear waves in fluid mechanics and plasma physics. Based on Hirota bilinear method and symbolic computation, we present lump and lump–soliton interaction solutions of the vcKP equation. These local solutions are derived by taking the auxiliary function as the positive quadratic function or the linear combination of the positive quadratic function and the exponential function. Compared with the results allowed by the constant-coefficient KP equation, lump and lump–soliton solutions for the vcKP equation possess more abundant properties. It is shown that the velocity, moving path, and maximum height of the lump are completely characterized by the time functions rather than the constant parameters. The interaction between a lump and one line soliton are still nonelastic, but the track of the lump obeys the controllable function of time. The lump interacting with resonance soliton pairs exhibits a kind of special rogue wave in which the peak emerges and evolves with the varying path. The detailed analysis and discussion of these solutions are provided and illustrated.