Details

Autor(en) / Beteiligte

• Mihai, Diana
• Velişcu, Andreea
• Comandaşu, Diana Elena
• Coroleucă, Cătălin Bogdan
• Coroleucă, Ciprian Andrei
• Mehedinţu, Claudia
• Bordea, Alina Elena
• Braga, Mihaela
• Nadă, Elena Silvia
• Bratu, Ovidiu Gabriel

Titel

FREEZE-ALL STRATEGY: PREGNANCY RATE, OBSTETRICAL PROGNOSIS AND ETHICAL CONSIDERATIONS - REVIEW EVALUATING 278.000 NEWBORNS AFTER ART

Ist Teil von

• Research and science today, 2019-01, p.102-119

Ort / Verlag

Targu-Jiu: University Constantin Brancusi of Târgu-Jiu

Erscheinungsjahr

2019

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• Uterine contractility can also be increased in the same cycle, and the implantation window is sometimes missed at the time of transfer27. 2.Placentation and associated obstetric complications In addition to the number of pregnancies that are lower in the fresh embryo group, it appears that ovarian hyperstimulation drugs also affect the development of pregnancy, placenta is altered in the case of ET in the same stimulation cycle28 and so many obstetric complications associated with this process occur29. [...]in the case of frozen embryos, a better pregnancy prognosis [95% CI] was observed: the fetus had a lower risk of being small for gestational age RR: 0.59, reduced gestational weight RR: 0.74, premature delivery RR: 0.74, but higher risk of RR: 1.10 cesarean and larger for gestational age RR: 1.4930. [...]the interesting discovery is that intrinsic factors rather than extrinsic factors influence the embryo's division process and the occurrence of the twin pregnancy after single transfer50. Logistic regression analysis showed that patients under 35 years old with high quality recovered oocytes and increased number of day 3 or 5 embryos of superior quality had the highest monozygotic pregnancy rates (3.1%), regardless of use ICSI or assisted hatching [p <0.01]. [...]the hypothesis regarding the damage to the pellucid area and hernia of the blastomere with the subsequent embryo division and the monozygotic pregnancy outcome is negated. [...]cryopreserved embryo transfer (FET) is an independent risk factor for placenta accreta, 3 times higher than for pregnancies using fresh embryos (ET), although the exact mechanism is not yet known54.