Details

Autor(en) / Beteiligte

• Cui, Hai‐Lei
• Liu, Si
• Jiang, Lu

Titel

Catalyst‐Free Synthesis of Novel Dimeric Tetrahydroisoquinoline Derivatives through [2+2+2] Annulation

Ist Teil von

• European journal of organic chemistry, 2019-08, Vol.2019 (30), p.4941-4950

Ort / Verlag

Weinheim: Wiley Subscription Services, Inc

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A simple, straightforward, and atom economic catalyst‐free [2+2+2] annulation of dihydroisoquinolines and allenoates has been developed. A diverse range of novel dimeric tetrahydroisoquinoline derivatives can be prepared in moderate to good yields (37–87 %) from readily available material. Dihydro‐β‐carboline can also be used in this reaction system delivering corresponding dimeric dihydro‐β‐carboline derivatives. Notably, the reaction could be easily scaled up to gram scale. The easy scale‐up of this process may provide structurally diversified natural product‐like molecules possessing privileged scaffold for potential application in biomedical research and other research fields. Interestingly, in contrast to the α,β‐selectivity observed in our previous study, β,γ‐selective [2+2+2] annulation was preferred in this work. A simple, straightforward and atom economic catalyst‐free [2+2+2] annulation of dihydroisoquinolines and allenoates has been developed, delivering a diverse range of novel dimeric tetrahydroisoquinoline derivatives (37–87 %) from readily available materials.