Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
A Review on Current Applications of Bilayer Tablets
Ist Teil von
Research journal of pharmacy and technology, 2019-05, Vol.12 (5), p.2539-2544
Ort / Verlag
Raipur: A&V Publications
Erscheinungsjahr
2019
Link zum Volltext
Quelle
Free E-Journal (出版社公開部分のみ）
Beschreibungen/Notizen
Both drugs are sustained release. Because of Metformin Hydrochloride is a highly water-soluble drug with high dose (500 mg), there leads to difficulty in providing an extended release rate from formulation and there might be problems in controlling the initial burst of drug from such formulation. [...]both the drugs show incompatibility with each other, and there arises a need to develop such a system to avoid intimate contact between the two drugs, i.e. sustained release bilayer tablet formulation of Glipizide& Metformin HCl using various polymers such as Hydroxyl Propyl Methyl Cellulose K15 M, Hydroxy Ethyl Cellulose and Ethylcellulose at different concentration15. From the results, Bilayer tablet showed an initial burst effect to provide a dose of immediate release layer Telmisartan to control the blood pressure level and the sustained release of Metformin HCl, for 10 hours, to control the blood glucose level. [...]they were formulated as sustained release matrix tablets.