Details

Autor(en) / Beteiligte

• Panda, Bijoy Kumar
• George, Ruth Susan
• Parekh, Neha Vijay
• Dharmadhikari, Adhiraj
• Patil, Sandeep

Titel

Evaluation and comparison of the utilization of anti‐epileptic drugs in Indian paediatric patients with global usage data

Ist Teil von

• Journal of pharmaceutical health services research, 2019-09, Vol.10 (3), p.365-371, Article jphs.12315

Ort / Verlag

London: Wiley Subscription Services, Inc

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Objectives To evaluate the utilization pattern of anti‐epileptic drugs (AEDs) in Indian paediatric patients and compare it with the global usage data. Methods Paediatric patients (≤18 years) with a confirmed diagnosis of epilepsy and prescribed with at least one AED were included in the study from a child neurology clinic in Pune, Maharashtra, India. The data pertaining to the type of epilepsy, and drug therapy was obtained retrospectively. The prescribing pattern of AEDs was identified and compared with the drug utilization pattern of the Asian and European countries from a systemic literature review. Key findings Out of the 343 paediatric patients enrolled in the study, 55.6% were males. Thirty‐four per cent of the patients were under the age group of 2–6 years. More than half (60.5%) of the patients were diagnosed with generalized seizures, with tonic–clonic seizures (48%) being the most common among them. Out of the 37.9% of patients diagnosed with partial epilepsy, simple partial seizure was the most common type. The most commonly prescribed drug was sodium valproate for both generalized and partial seizures. Levetiracetam was found to be the preferred newer AED for management of generalized epilepsy. Similar prescribing pattern was seen in Asian countries where sodium valproate was the most preferred AED followed by levetiracetam and oxcarbazepine. Sodium valproate was also highly prescribed in European countries while levetiracetam and oxcarbazepine were underused. Two hundred and seven patients (60%) were managed on monotherapy. Conclusions Older generation AEDs are still used in majority of patients as mono and dual therapy. Among the newer generation AEDs, there is an increase in the utilization of levetiracetam. Prescription of AEDs in our study goes in line with Asian countries but differs with the European counterparts due to various reasons.