Details

Autor(en) / Beteiligte

• Yuan, Ye
• Gu, Zi
• Yao, Chi
• Luo, Dan
• Yang, Dayong

Titel

Nucleic Acid–Based Functional Nanomaterials as Advanced Cancer Therapeutics

Ist Teil von

• Small (Weinheim an der Bergstrasse, Germany), 2019-06, Vol.15 (26), p.e1900172-n/a

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2019

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Nucleic acid–based functional nanomaterials (NAFN) have been widely used as emerging drug delivery nanocarriers for cancer therapeutics. Considerable works have demonstrated that NAFN can effectively load and protect therapeutic agents, and particularly enable targeting delivery to the tumor site and stimuli‐responsive release. These outstanding performances are due to NAFN's unique properties including inherent biological functions and sequence programmability as well as biocompatibility and biodegradability. In this Review, the recent progress on NAFN as advanced cancer therapeutics is highlighted. Three main cancer therapy approaches are categorized including chemo‐, immuno‐, and gene‐therapy. Examples are presented to show how NAFN are rationally and exquisitely designed to address problems in cancer therapy. The challenges and future development of NAFN are also discussed toward future more practical biomedical applications. Nucleic acid–based functional nanomaterials (NAFN) have been widely used as emerging drug delivery nanocarriers. In this Review, the recent progress on NAFN as advanced cancer therapeutics is highlighted. Examples are presented to show how NAFN are rationally designed to address the problems in cancer therapy. The challenges and future development of NAFN toward biomedical applications are also discussed.