Details

Autor(en) / Beteiligte

• Zhao, Bo‐Liang
• Lin, Ye
• Du, Da‐Ming

Titel

Enantioselective Construction of Bispirooxindoles via Squaramide‐Catalysed Cascade Michael/Cyclization Reaction

Ist Teil von

• Advanced synthesis & catalysis, 2019-07, Vol.361 (14), p.3387-3393

Ort / Verlag

Heidelberg: Wiley Subscription Services, Inc

Erscheinungsjahr

2019

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• A series of readily available 2‐(2‐oxoindolin‐3‐yl)malononitriles bearing multiple active sites were first used in asymmetric catalytic synthesis, which have been successfully applied to develop a bifunctional squaramide‐catalyzed cascade Michael/cyclization reaction strategy. Various cyclopentene‐bispirooxindoles with three continuous stereocenters, two of which are quaternary spiro‐stereocenters, were constructed in good yields with excellent stereoselectivities (up to >20:1 dr, >99% ee).