Details

Autor(en) / Beteiligte

• Casas, C.
• Ginisty, H.
• Alvarez-Georges, S.
• Viodé, C.
• Lejeune, O.
• Rouvrais, C.
• Schmitt, A.M.
• Redoulès, D.

Titel

Molecular Characterization of Inflammation and Staphylococcus aureus Colonization of Involved Skin of Atopic Dermatitis Patients

Ist Teil von

• Skin pharmacology and physiology, 2008-01, Vol.21 (5), p.260-268

Ort / Verlag

Basel, Switzerland: S. Karger AG

Erscheinungsjahr

2008

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Atopic dermatitis (AD) is a multifactorial chronic inflammatory disease mainly stemming from a genetic predisposition that leads to hypersensitivity to environmental factors and a common involvement of Staphylococcus aureus (SA) colonization. The aim of this work was to propose a new non-invasive approach to enumerate the genes coding for the toxins of SA in atopic skin samples. In parallel, the study aimed to evaluate the change in AD through 3 markers of the inflammatory response: IL-8, IL-1RA/IL-1α and IL-18. These methods were tested on 31 patients with AD, and finally on a group of 19 subjects for whom clinical improvement had been reported after various treatments. The study revealed the presence of a large number of genes encoding toxins in atopic samples, indicating a high rate of SA colonization, and also an increase in the level of all cytokine markers in atopic skin compared to the skin of healthy subjects. Finally, we found a positive correlation between increases in the SCORAD (Scoring Atopic Dermatitis Index) value after treatment and the corresponding evolution of the SA density. These methods provide a means to clinically evaluate the course of AD, and may help in the development of potential treatments.