Details

Autor(en) / Beteiligte

• Patrono, Carlo

Titel

Aspirin as an Antiplatelet Drug

Ist Teil von

• The New England journal of medicine, 1994-05, Vol.330 (18), p.1287-1294

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

1994

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• The past 10 years have witnessed major changes in our understanding of the pathophysiologic mechanisms underlying vascular occlusion 1 , 2 and considerable progress in the clinical assessment of aspirin and other antiplatelet agents 3 – 5 . The purpose of this review is to describe a rational basis for antithrombotic prophylaxis and treatment with aspirin. Basic information on the molecular mechanism of action of aspirin in inhibiting platelet function will be integrated with the appropriate clinical pharmacologic data and the results of randomized clinical trials. Mechanism of Action Aspirin induces a long-lasting functional defect in platelets, clinically detectable as a prolongation of the . . .