Details

Autor(en) / Beteiligte

• Hurt, Richard D
• Sachs, David P.L
• Glover, Penny N
• Glover, Elbert D
• Offord, Kenneth P
• Johnston, J. Andrew
• Dale, Lowell C
• Khayrallah, Moise A
• Schroeder, Darrell R
• Sullivan, C. Rollynn
• Sullivan, Pamela M
• Croghan, Ivana T

Titel

A Comparison of Sustained-Release Bupropion and Placebo for Smoking Cessation

Ist Teil von

• The New England journal of medicine, 1997-10, Vol.337 (17), p.1195-1202

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

1997

Quelle

MEDLINE

Beschreibungen/Notizen

• Pharmacologic treatments such as nicotine-replacement therapy have been shown to help smokers stop smoking. Using a medication that does not contain nicotine, such as an antidepressant, has intrigued investigators for several reasons. Smokers are more likely to have a history of major depression than nonsmokers, 1 , 2 and nicotine may act as an antidepressant in some smokers. 3 , 4 The development of a depressed affect or depression after smoking cessation may lead to relapse. 5 – 7 Results of clinical trials of antidepressant therapy for smoking cessation have been mixed. The initial experience with doxepin was promising; however, no large trials have been reported. . . .