Details

Autor(en) / Beteiligte

• Krack, Paul
• Batir, Alina
• Van Blercom, Nadège
• Chabardes, Stephan
• Fraix, Valérie
• Ardouin, Claire
• Koudsie, Adnan
• Limousin, Patricia Dowsey
• Benazzouz, Abdelhamid
• LeBas, Jean François
• Benabid, Alim-Louis
• Pollak, Pierre

Titel

Five-Year Follow-up of Bilateral Stimulation of the Subthalamic Nucleus in Advanced Parkinson's Disease

Ist Teil von

• The New England journal of medicine, 2003-11, Vol.349 (20), p.1925-1934

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

2003

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• In this five-year follow-up study, patients with advanced Parkinson's disease who were treated with bilateral stimulation of the subthalamic nucleus sustained marked improvements in motor function and in their ability to perform activities of daily living when tested 8 to 12 hours after the last dose of dopaminergic medication (off medication), and in dyskinesia while receiving maximal benefit from medication (on medication). However, akinesia, speech, postural stability, freezing episodes, and cognitive function worsened between the first year and the fifth year of follow-up, as is consistent with the natural history of Parkinson's disease. Sustained improvements in a five-year follow-up study. Levodopa is the standard treatment for Parkinson's disease but causes long-term motor complications despite other pharmacologic interventions. 1 In 1998, we reported that the first series of patients with Parkinson's disease who were treated with bilateral stimulation of the subthalamic nucleus 2 had improvement in motor function while off medication one year after surgery. We also reported an associated improvement in on-medication dyskinesia and off-medication dystonia. 3 , 4 These findings have been confirmed by other groups, 5 , 6 but little information about the long-term outcome of this therapy has been published. We report here the results of a five-year prospective cohort study of the . . .