Details

Autor(en) / Beteiligte

• Steinbach, Gideon
• Lynch, Patrick M
• Phillips, Robin K.S
• Wallace, Marina H
• Hawk, Ernest
• Gordon, Gary B
• Wakabayashi, Naoki
• Saunders, Brian
• Shen, Yu
• Fujimura, Takashi
• Su, Li-Kuo
• Levin, Bernard
• Godio, Louis
• Patterson, Sherri
• Rodriguez-Bigas, Miguel A
• Jester, Susan L
• King, Karen L
• Schumacher, Marta
• Abbruzzese, James
• DuBois, Raymond N
• Hittelman, Walter N
• Zimmerman, Stuart
• Sherman, Jeffrey W
• Kelloff, Gary

Titel

The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor, in Familial Adenomatous Polyposis

Ist Teil von

• The New England journal of medicine, 2000-06, Vol.342 (26), p.1946-1952

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

2000

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Human colon cancer develops in a stepwise fashion from normal mucosa to adenomatous polyps to carcinoma. Mutation in the adenomatous polyposis coli ( APC ) gene commonly occurs early in the development of sporadic adenomas. 1 Patients with familial adenomatous polyposis have an inherited germ-line APC mutation 2 that results in hundreds of adenomatous polyps and a nearly 100 percent risk of colon cancer. Management includes prophylactic proctocolectomy, or colectomy followed by sigmoidoscopic surveillance and rectal polypectomy. Because the adenoma-to-carcinoma sequence in familial adenomatous polyposis resembles sporadic colon carcinogenesis, 1 studies of familial adenomatous polyposis may contribute to the prevention of sporadic adenomas . . .