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Modafinil for Excessive Sleepiness Associated with Shift-Work Sleep Disorder
Ist Teil von
The New England journal of medicine, 2005-08, Vol.353 (5), p.476-486
Ort / Verlag
Boston, MA: Massachusetts Medical Society
Erscheinungsjahr
2005
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
About 1 of 10 night-shift workers suffers from severe excessive sleepiness on the job. This realization has led to the development of specific diagnostic criteria for people affected with shift-work sleep disorder. In this multicenter study, patients meeting this case definition were treated with placebo or modafinil. Although there was a significant improvement in laboratory measures of sleep, treated patients were still quite sleepy.
Modafinil improves performance among patients with shift-work sleep disorder but does not come close to returning them to a normal level of sleepiness.
Nearly 6 million Americans work at night on a permanent or rotating basis.
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Night-shift work disrupts both sleep and waking because of the misalignment of circadian regulation and sleep–wake behavior.
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,
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In about 5 to 10 percent of night-shift workers, the sleep–wake disturbance is severe enough to warrant diagnosis as shift-work sleep disorder,
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–
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which is characterized by a level of excessive sleepiness during night work and insomnia when attempting to sleep in the daytime that is judged to be clinically significant.
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,
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Persons with shift-work sleep disorder miss family and social activities more frequently and have higher rates of . . .