Details

Autor(en) / Beteiligte

• Heydendael, Vera M.R
• Spuls, Phyllis I
• Opmeer, Brent C
• de Borgie, Corianne A.J.M
• Reitsma, Johannes B
• Goldschmidt, Wouter F.M
• Bossuyt, Patrick M.M
• Bos, Jan D
• de Rie, Menno A

Titel

Methotrexate versus Cyclosporine in Moderate-to-Severe Chronic Plaque Psoriasis

Ist Teil von

• The New England journal of medicine, 2003-08, Vol.349 (7), p.658-665

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

2003

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• Although methotrexate and cyclosporine are both effective treatments for psoriasis, their comparative efficacy has not been established. This trial compared the two drugs and found them to be similarly effective. Each was associated with specific but limited side effects. The two drugs are similarly effective in moderate-to-severe psoriasis. Chronic plaque psoriasis is a skin disease characterized by sharply demarcated, erythematous, squamous lesions, with an estimated worldwide prevalence of 0.1 to 3 percent. 1 Various therapies are available for the treatment of psoriasis, including topical ointments, such as calcipotriene, corticosteroids, tar, and anthralin; phototherapy with ultraviolet B radiation (UVB) and methoxsalen (psoralen) with ultraviolet A radiation (PUVA); systemic drugs such as acitretin; and the systemic immunosuppressant drugs methotrexate and cyclosporine. 2 , 3 Methotrexate and cyclosporine are often used in daily clinical practice, but which of the two is more effective has not been established. The current management of severe psoriasis is . . .