Details

Autor(en) / Beteiligte

• Beckett, Nigel S
• Peters, Ruth
• Fletcher, Astrid E
• Staessen, Jan A
• Liu, Lisheng
• Dumitrascu, Dan
• Stoyanovsky, Vassil
• Antikainen, Riitta L
• Nikitin, Yuri
• Anderson, Craig
• Belhani, Alli
• Forette, Françoise
• Rajkumar, Chakravarthi
• Thijs, Lutgarde
• Banya, Winston
• Bulpitt, Christopher J

Titel

Treatment of Hypertension in Patients 80 Years of Age or Older

Ist Teil von

• The New England journal of medicine, 2008-05, Vol.358 (18), p.1887-1898

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• In this study, patients 80 years of age or older with sustained systolic hypertension were randomly assigned to receive either the diuretic indapamide, with or without the angiotensin-converting–enzyme inhibitor perindopril, or matching placebos, for a target blood pressure of 150/80 mm Hg. Active treatment resulted in a nearly significant reduction of the risks of fatal or nonfatal stroke and death from cardiovascular causes and a significant reduction in the rates of death from stroke and death from any cause, suggesting that antihypertensive treatment in these persons may be beneficial. In this controlled trial in patients with sustained systolic hypertension, active treatment resulted in a nearly significant reduction of the risks of fatal or nonfatal stroke and death from cardiovascular causes. There was a significant reduction in the rates of death from stroke and death from any cause. Blood-pressure reduction is effective in preventing stroke and other vascular events, including heart failure. 1 In the past decade, treatment benefits have appeared to be broadly consistent among a range of subpopulations and among antihypertensive agents. 2 However, as highlighted by earlier 3 and more recent 4 guidelines, evidence that treating patients 80 years of age or older is beneficial is inconclusive. Although the risk of stroke increases continuously with increasing blood pressures above approximately 115/75 mm Hg, the association of blood pressure and stroke attenuates with increasing age. 1 Epidemiologic population studies have consistently suggested that blood pressure and the risk of death are . . .