Details

Autor(en) / Beteiligte

• Finfer, Simon
• Chittock, Dean R
• Su, Steve Yu-Shuo
• Blair, Deborah
• Foster, Denise
• Dhingra, Vinay
• Bellomo, Rinaldo
• Cook, Deborah
• Dodek, Peter
• Henderson, William R
• Hébert, Paul C
• Heritier, Stephane
• Heyland, Daren K
• McArthur, Colin
• McDonald, Ellen
• Mitchell, Imogen
• Myburgh, John A
• Norton, Robyn
• Potter, Julie
• Robinson, Bruce G
• Ronco, Juan J

Titel

Intensive versus Conventional Glucose Control in Critically Ill Patients

Ist Teil von

• The New England journal of medicine, 2009-03, Vol.360 (13), p.1283-1297

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2009

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• In this study, adults who were expected to require treatment in the intensive care unit on 3 or more consecutive days were randomly assigned to undergo intensive blood glucose control (target range, 81 to 108 mg per deciliter [4.5 to 6.0 mmol per liter]) or conventional blood glucose control (180 mg per deciliter [10.0 mmol per liter]). The primary end point was death from any cause within 90 days after randomization. Intensive glucose control increased mortality among the patients. Adults who were expected to require treatment in the intensive care unit on 3 or more consecutive days were randomly assigned to undergo intensive or conventional blood glucose control. Intensive glucose control increased mortality among the patients. Hyperglycemia is common in acutely ill patients, including those treated in intensive care units (ICUs). 1 The occurrence of hyperglycemia, in particular severe hyperglycemia, is associated with increased morbidity and mortality in a variety of groups of patients, 2 – 5 but trials examining the effects of tighter glucose control have had conflicting results. 6 – 13 Systematic reviews and meta-analyses have also led to differing conclusions. 14 , 15 Nevertheless, many professional organizations recommend tight glucose control for patients treated in ICUs. 16 , 17 Barriers to widespread adoption of tight glucose control include the increased risk of severe hypoglycemia, 14 concerns about the external validity of some studies, . . .