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The New England journal of medicine, 2009-09, Vol.361 (12), p.1188-1188
Ort / Verlag
Waltham, MA: Massachusetts Medical Society
Erscheinungsjahr
2009
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
An 80-year-old woman presented with longitudinal melanonychia, or longitudinal dark pigmentation of the nails (arrows). She first noticed it more than a year after the start of hydroxyurea treatment for essential thrombocythemia. Although all nails can be affected, in this patient only the two thumbnails were involved. She had no other side effects of therapy, and no other mucocutaneous hyperpigmentation was observed. At the time of presentation, she was not taking other drugs implicated in nail discoloration and had no symptoms attributable to essential thrombocythemia. The platelet count was 420×10
9
per liter. Melanonychia is a rare side effect of hydroxyurea . . .