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ACE gene and physical activity, blood pressure, and hypertension: a population study in Finland
Ist Teil von
Journal of applied physiology (1985), 2002-06, Vol.92 (6), p.2508-2512
Ort / Verlag
Bethesda, MD: Am Physiological Soc
Erscheinungsjahr
2002
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
1 Department of Public Health and General Practice,
Faculty of Medicine, University of Kuopio, FIN-70211
Kuopio; and 2 Department of Epidemiology and Health
Promotion, National Public Health Institute, and
3 Department of Public Health, University of Helsinki,
FIN-00014 Helsinki, Finland
The study evaluated the
association of the insertion/deletion polymorphism of the
angiotensin-converting enzyme gene (ACE I/D) with self-reported
moderate-intensity leisure time physical activity (MILTPA), arterial
blood pressure (BP) and history of hypertension (HT). A representative
population-based sample of 721 middle-aged adults (358 women) from two
areas of Finland was genotyped for the ACE I/D. After exclusion
criteria were applied, 455 subjects (288 women) were selected for the
analysis. The distribution of the ACE I/D genotypes did not differ
significantly among frequent vs. nonfrequent MILTPA groups
( 2 = 2.556; df = 2; P value = 0.279). The main predictors of BP were male gender, age, body mass
index, and arterial pulse. Additionally, tobacco smoking and alcohol
consumption also had a significant main effect on diastolic BP. HT was
significantly more frequent in subjects with obesity, family history of
cardiovascular disease, or lower educational level. As for BP, neither
ACE I/D nor MILTPA was associated with HT. The study confirmed recent
reports from population-based studies of no association between ACE I/D
and physical fitness. The study also confirmed a lack of association between ACE I/D and BP or HT.
polymorphism; leisure time; exercise; fitness; association