Details

Autor(en) / Beteiligte

• Balachandar, R.
• Karmegam, N.
• Subbaiya, R.

Titel

Extraction, separation and characterization of bioactive compounds produced by Streptomyces isolated from vermicast soil

Ist Teil von

• Research journal of pharmacy and technology, 2018-10, Vol.11 (10), p.4569-4574

Ort / Verlag

Raipur: A&V Publications

Erscheinungsjahr

2018

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• There are more than 200 known diseases transmitted by bacteria, fungi, viruses and prions, rickettsia and other microbes to humans3,4. [...]it is good to turn an eye to nature to find antagonistic microorganisms and metabolites5. Thousands of antibiotics were isolated from Streptomyces, these represents only a small fraction of bioactive compounds produced21,22. [...]identification of Streptomyces from natural resources and characterization of bioactive compounds is valuable endeavour. Other important constituents of GCMS analysis showed the presence of long chain unsaturated fatty acid (oleic acid ) which are bactericidal to important human pathogenic microorganisms, including methicillin-resistant Staphylococcus aureus50, Helicobacter pylori51, Candida albicans52 and also inhibits the bacterial enoyl-acyl carrier protein reductase (Fab1), an essential component of bacterial fatty acid synthesis which has served as a promising target for antimicrobial drugs. According to Lancini et al.56, the activity of an antibiotic is defined and measured in terms of its ability to inhibit microbial growth (bacteria, fungi) and protozoa.