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Journal of Nuclear Medicine, 2008-06, Vol.49 (Suppl_2), p.43S-63S
Ort / Verlag
United States: Soc Nuclear Med
Erscheinungsjahr
2008
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
Molecular imaging of tumor metabolism has gained considerable interest, since preclinical studies have indicated a close relationship between the activation of various oncogenes and alterations of cellular metabolism. Furthermore, several clinical trials have shown that metabolic imaging can significantly impact patient management by improving tumor staging, restaging, radiation treatment planning, and monitoring of tumor response to therapy. In this review, we summarize recent data on the molecular mechanisms underlying the increased metabolic activity of cancer cells and discuss imaging techniques for studies of tumor glucose, lipid, and amino acid metabolism.