UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 21 von 8457
Datensatz exportieren als...
BibTeX
Effects of Acute Fluorene‐9‐Bisphenol Exposure on Mouse Oocyte in vitro Maturation and Its Possible Mechanisms
Environmental and molecular mutagenesis, 2019-04, Vol.60 (3), p.243-253
Jiao, Xiao‐Fei
Liang, Qiu‐Man
Wu, Di
Ding, Zhi‐Ming
Zhang, Jia‐Yu
Chen, Fan
Wang, Yong‐Sheng
Zhang, Shou‐Xin
Miao, Yi‐Liang
Huo, Li‐Jun
2019
Details
Autor(en) / Beteiligte
Jiao, Xiao‐Fei
Liang, Qiu‐Man
Wu, Di
Ding, Zhi‐Ming
Zhang, Jia‐Yu
Chen, Fan
Wang, Yong‐Sheng
Zhang, Shou‐Xin
Miao, Yi‐Liang
Huo, Li‐Jun
Titel
Effects of Acute Fluorene‐9‐Bisphenol Exposure on Mouse Oocyte in vitro Maturation and Its Possible Mechanisms
Ist Teil von
Environmental and molecular mutagenesis, 2019-04, Vol.60 (3), p.243-253
Ort / Verlag
Hoboken, USA: John Wiley & Sons, Inc
Erscheinungsjahr
2019
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
Fluorene‐9‐bisphenol (BHPF), a substitute of bisphenol A (BPA) used in the production of the so‐called “BPA‐free” plastics, has now been shown to be released from commercial plastic bottles into drinking water and has strong anti‐estrogenic activity in mice, which suggests that BHPF is also an environmental toxin. However, whether BHPF exposure has effects on mouse oocyte development is unknown. In this study, the influence of acute exposure to BHPF (50–150 μM, 12 hr) on mouse oocyte maturation and its possible mechanisms were investigated. Of note, 50‐μM BHPF had no effects on the maturation of mouse oocytes, whereas 100‐ and 150‐μM BHPF significantly blocked germinal vesicle breakdown and led to the failure of first polar body extrusion. Particularly, 100‐μM BHPF exposure severely decreased the cellular adenosine triphosphate in a time‐dependent manner, which finally brought out the loss of spindles. In addition, the actin cytoskeleton was also impaired. The defective mitochondrial dynamics and decreased mitochondrial DNA implied the damage of mitochondria in BHPF‐treated oocytes. Increased PINK1, Beclin1, and LC3B protein level and decreased TOMM20 and TOMM17A protein level illustrated that mitophagy was induced, which also confirmed that BHPF exposure impaired the cellular mitochondria. Moreover, BHPF induced reactive oxygen species accumulation and early apoptosis. Oocyte quality was also impaired by BHPF exposure through altering histone modifications evidenced by increased H3K9me3 and H3K27me3 levels. Collectively, our results indicated that BHPF exposure disrupted mouse oocyte maturation and reduced oocyte quality through affecting cytoskeleton architecture, mitochondrial function, oxidative stress, apoptosis, and histone modifications. Environ. Mol. Mutagen. 60:243–253, 2019. © 2018 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0893-6692
eISSN: 1098-2280
DOI: 10.1002/em.22258
Titel-ID: cdi_proquest_journals_2188978728
Format
–
Schlagworte
Actin
,
Actin Cytoskeleton - pathology
,
Adenosine triphosphate
,
Adenosine Triphosphate - metabolism
,
Animals
,
Apoptosis
,
Apoptosis - drug effects
,
ATP
,
Beclin-1 - metabolism
,
Benzhydryl Compounds - toxicity
,
Bisphenol A
,
Cell Differentiation - drug effects
,
Cytoskeleton
,
Deoxyribonucleic acid
,
DNA
,
DNA damage
,
DNA, Mitochondrial - analysis
,
Drinking water
,
Estrogenic activity
,
Exposure
,
Extrusion
,
Fluorene
,
Fluorenes - toxicity
,
fluorene‐9‐bisphenol
,
Maturation
,
Membrane Transport Proteins - metabolism
,
Mice
,
Microtubule-Associated Proteins - metabolism
,
Mitochondria
,
Mitochondria - pathology
,
Mitochondrial DNA
,
Mitochondrial Dynamics - drug effects
,
Mitophagy - drug effects
,
mouse oocyte
,
Oocytes
,
Oocytes - cytology
,
Oocytes - growth & development
,
Oxidative stress
,
Oxidative Stress - drug effects
,
Phenols
,
Phenols - toxicity
,
Plastics - analysis
,
Polymers
,
Protein Kinases - metabolism
,
Proteins
,
PTEN-induced putative kinase
,
Reactive oxygen species
,
Reactive Oxygen Species - metabolism
,
Receptors, Cell Surface - metabolism
,
spindle assembly
,
Spindles
,
Time dependence
,
Xenoestrogens
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX