Details

Autor(en) / Beteiligte

• Downer, M V
• Hodge, T
• Smith, D K
• Qari, S H
• Schuman, P
• Mayer, K H
• Klein, R S
• Vlahov, D
• Gardner, L I
• McNicholl, J M

Titel

Regional variation in CCR5-[Delta]32 gene distribution among women from the US HIV Epidemiology Research Study (HERS)

Ist Teil von

• Genes and immunity, 2002-08, Vol.3 (5), p.295

Ort / Verlag

Hamilton: Nature Publishing Group

Erscheinungsjahr

2002

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The CCR5-Delta32 genotype is known to influence HIV-1 transmission and disease. We genotyped 1301 US women of various races/ethnicities participating in the HIV Epidemiologic Research Study. None was homozygous for CCR5-Delta32. The distribution of heterozygotes was similar in HIV-1 infected and uninfected women. Thirty-seven (11.8%) white, 28 (3.7%) blacks/African Americans (AA), seven (3.3%) Hispanics/Latinas, and one (6.6%) other race/ethnicity were heterozygous. The frequency of heterozygotes differed among sites for all races combined (P = 0.001). More heterozygotes were found in AA women in Rhode Island (8.9%) than in the other sites (3.1%) (P = 0.02), while heterozygosity in white women was most common in Maryland (28.6%) (P = 0.025). These regional differences could be accounted for by racial admixture in AAs, but not in whites. Regional variations should be considered when studying host genetic factors and HIV-1 in US populations.