Trends in neurosciences (Regular ed.), 2002-07, Vol.25 (7), p.327-329
2002
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Details
- Autor(en) / Beteiligte
- Titel
- Tau neurotoxicity without the lesions: a fly challenges a tangled web
- Ist Teil von
- Trends in neurosciences (Regular ed.), 2002-07, Vol.25 (7), p.327-329
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2002
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- Models of neurodegenerative disorders are challenging the classical defining role of tangles in neurotoxicity. In flies, tau overexpression is sufficient to cause neuronal death without the formation of fibrillar aggregates. This parallels observations in models of polyglutamine disorders and suggests that aggregated protein might not be the toxic species responsible for neuronal dysfunction and cell death. Fly models challenge the causal role of tau aggregation and tangles in neurodegeneration.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0166-2236eISSN: 1878-108XDOI: 10.1016/S0166-2236(02)02170-7Titel-ID: cdi_proquest_journals_218715975
- Format
- –
- Schlagworte
- alzheimer, Animals, Brain - metabolism, Brain - pathology, Brain - physiopathology, Disease Models, Animal, Drosophila melanogaster - genetics, Drosophila melanogaster - metabolism, Humans, Mice, Mice, Transgenic - genetics, Mice, Transgenic - metabolism, Mutation - genetics, neurodegeneration, Neurology, Neurons - metabolism, Neurons - pathology, Neurotoxicity, parkinson, tau Proteins - genetics, tau Proteins - metabolism, Tauopathies - genetics, Tauopathies - metabolism, Tauopathies - physiopathology, tauopathy, wingless