Details

Autor(en) / Beteiligte

• ZANDER, Thomas
• NETTEKOVEN, Willy
• KRAUS, Jürgen A
• PELS, Hendrik
• KO, Yon D
• VETTER, Hans
• KLOCKGETHER, Thomas
• SCHLEGEL, Uwe

Titel

Intensified PCV-chemotherapy with optional stem cell support in recurrent malignant oligodendroglioma

Ist Teil von

• Journal of neurology, 2002-08, Vol.249 (8), p.1055-1057

Ort / Verlag

Berlin: Springer

Erscheinungsjahr

2002

Quelle

MEDLINE

Beschreibungen/Notizen

• Six patients with recurrent or progressive anaplastic oligodendroglial tumors after surgical treatment and irradiation were treated with six/seven cycles of intensified PCV: Vincristine (1 mg/m(2)), CCNU (50 mg/m(2)) d.1,15 and procarbazine (75 mg/m(2)) d.2 to 29. If leukocytopenia (< 2.500/microl) or thrombocytopenia (< 75.000/microl) developed, 1 x 10(6) CD34(+) autologous stem cells/ kg body weight were reinfused three days after completion of subsequent cycles. Complete response was seen in 2/6 and partial response in 4/6 patients. Median follow up from time of recurrence was 35 months, progression free survival was 18 to > 39 months and overall survival 23 to > 39 months. We conclude that intensified PCV with stem cell support is feasable in recurrent/progressive anaplastic oligodendroglial tumors and appears to be sufficiently well tolerated to allow further study.